Contact with the Crucible?

I was doing another playthrough recently and happened on the Winged Misbegotten Ashes. It’s pretty commonly accepted that misbegotten/omen/etc are touched by the crucible, but the ash’s item description references what seems like an “event” where the crucible was “contacted”. From the ash:

“The misbegotten are held to be a punishment for making contact with the Crucible, and from birth they are treated as slaves, or worse.”

So what event would this “making contact” be referring to? I had always understood the mutations present in misbegotten to just be a result of evolution, a sort of return to an earlier genetic morphology - but this Ash seems to be referring to some discovery of the crucible that then may have elicited a punishment. Is there any info on what the discovery of the crucible may have entailed?