For serious relationships do women really care about pickup lines?

For the longest time I thought pickup lines were some cheesy artifact of dating history, but based on what I'm seeing from other people it seems to still be a thing.

I'd like to think that I'm a clever person in general, but when it comes to pickup lines as an intro I'm clueless.

For a serious relationship, does it generally make a difference if you open with a pickup line or is this part something you skip? I usually open with "Hey" or "How's it going?" and put more effort into subsequent messages. Am I going about this the wrong way?