Visiting from the UK

Me (31M) and my partner (25F) are visiting from the UK next year for 10-14 days. We haven't really decided on a month yet but probably May, I guess initially is there any reason not to visit in May? I'm looking for advice and recommendations on basically every aspect of the trip - it's always just better to hear from people that live in the city.

Recommendations for locals spots for drinks/food (both first time to the US so will probably want to try some of the big chains as well just for fun).

Neither of us drive, so will be relying on public transport and uber. How realistic is this? Where would be good (but not super expensive) areas to stay? Anywhere to avoid?

Is the city relatively safe? Are there any areas to straight up avoid going to?

Any advice on how to be a 'good' tourist in the US and Buffalo specifically? We know about tipping culture but that's about as far as it goes!

Any brits in here with specific advice?

Apologies this post is quite vague and probably really annoying.

Thanks x